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It is needed for energy production through the Krebs Cycle, for the synthesis of DNA via the folate cycle which affects trillions of cells in the body, and for the expression of genes through epigenetic processes

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Male SpragueDawley (SD) rats weighing 200 20 g were obtained from the Animal Experiment Center of the Fourth Military Medical University (Xian, China) and housed in a specific pathogen-free animal facility

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